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BioTechnologia
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1/2013
vol. 94
 
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abstract:
Commentary

A new division of bacterial UvrA homologues

Marta Marszałkowska
,
Magdalena Bil
,
Łukasz Kreft
,
Marcin Olszewski

BioTechnologia vol. 94(1) C pp. 54-56 C 2013
DOI: https://doi.org/10.5114/bta.2013.46439
Online publish date: 2014/10/23
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The UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type

nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise

additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over

2400 bacterial genomes and found 130 examples of bacteria containing uvrA2 genes. The sequence analyses

conducted on these UvrA homologues revealed that the previously established division of UvrA proteins might

be based on some incorrect assumptions. In this paper, we present the reasons for our creation of a new division

of UvrA homologues and a description of the four UvrA classes we have created.
 
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