eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
Current issue Archive About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
3/2020
vol. 101
 
Share:
Share:
more
 
 
abstract:
RESEARCH PAPERS

A recently developed approach in tumor therapy using Salmonella

MAHMOUD GHARBAVI
1, 2
,
GITI KARIMKHANLOOE
3
,
JAFAR AMANI
4
,
PARDIS KASHIAZARI
5
,
ALI SHARAFI
5

1.
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2.
Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
3.
School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4.
Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
5.
Department of Biology, Payame Noor University, Khoy, Iran
BioTechnologia vol. 101 (3) C pp. 253–267 C 2020
Online publish date: 2020/09/14
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
There are three main approaches in cancer treatment: surgery, chemotherapy, and radiotherapy. Recently, the use of bioengineered bacteria as therapeutic agents has been shown to have some valuable properties in the treatment of cancer, which do not exist in conventional approaches. Bacteria in particular can target tumors, and they can preferentially proliferate and accumulate within tumors and inhibit the growth of cancer cells by inducing cytotoxicity. Thus, bacteria can be easily detected in tumor sites. Moreover, bacteria-derived factors exert an immunostimulatory effect. Over the past decade, Salmonella, Clostridium, and other bacterial genera have been shown to inhibit tumor growth and promote the survival rate in animal models. Clinical trials for cancer treatment with bacteria have shown improved results by combination with other therapeutic methods such as chemotherapy or radioactive agents. This review is an effort to introduce the use of healthy bacteria in tumor therapy. We specifically focus on Salmonella, which has been extensively used in tumor therapy. Therefore, in this review study, we discuss the merits, mechanisms, and attenuated strains of a combination therapy compared to other therapeutic approaches in Salmonella-mediated cancer therapy
keywords:

cancer therapy, combination therapy, Salmonella , tumor targeting

 
Stosujemy się do standardu HONcode dla wiarygodnej informacji zdrowotnej This site complies with the HONcode standard for trustworthy health information: verify here