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BioTechnologia
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3/2020
vol. 101
 
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abstract:
RESEARCH PAPERS

Carotenoid accumulation in Dietzia maris NITD protects from macromolecular damage

Surojit Bera
1

1.
Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India
BioTechnologia vol. 101 (3) C pp. 171–178 C 2020
Online publish date: 2020/09/14
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Over the past decades, nutraceuticals have attracted considerable interest because of their potential nutritional,

safety and therapeutic effects. Carotenoid molecules are potent nutraceuticals with an attractive colour and have

been shown to play crucial roles in the immune system and susceptibility of organisms to certain diseases. Reactive oxygen species (ROS) are considered to be a major threat to cellular components and lead to protein oxidation, lipid peroxidation and DNA damage. In the present study, canthaxanthin (CX), an orange-red keto-carotenoid, was extracted from Dietzia maris NITD. Carbonyl content measurement showed that the presence of CX

can prevent protein oxidation in D. maris NITD. The inhibition of protein oxidation in vitro revealed a high correlation coefficient of the extracted CX with positive controls. Both the linoleic acid model (IC50 = 932.48 μg/ml)

and the goat liver model experiments showed that CX can also inhibit lipid peroxidation in vitro. CX from D. maris

NITD was also proved to be effective in maintaining the observable intactness of a model DNA (pBR322). The

present study indicated that bacterial CX can be a useful bioactive compound to prevent oxidative damage incurred by cellular macromolecules in terms of pharmaceutical and nutraceutical aspects.
keywords:

canthaxanthin, ROS, protein oxidation, nutraceutical, linoleic acid

 
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