Identification of amino acid sequences via X-ray crystallography: a mini review of case studies

The sequencing of a protein is a complicated issue. Several methods have been developed in order to establish

the amino acid sequences of proteins, including Edman degradation, LC/MS/MS and cDNA sequencing. A number

of examples confirm that X-ray crystallography could also be a useful tool for the identification of an amino acid

sequence of unknown proteins. Here, we present a short review summarizing the application of crystallography

for protein sequence determination and identification.