REVIEW PAPER
Deterministic models and stochastic simulations in multiple reaction models in systems biology

In this paper, we have overviewed deterministic and stochastic approaches for the modeling of bio-molecular

reactions in systems biology. We have described and compared different versions of stochastic simulation

approaches towards the modeling of bio-molecular reaction systems, the direct approach and the family of the tauleap

methods. We also have illustrated differences between different approaches by providing numerical examples

of computational analyses for selected models. Computational examples of application of stochastic simulation

algorithms involved two systems of different interacting bio-molecular species and one model from the area of

ecology, describing interactions between two animal populations. Apart from the direct approach and tau-leap

family of methods, we have also overviewed the so called hybrid algorithm of stochastic simulations, proven to

be very efficient when there are huge differences between reaction rates in the system.