eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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2/2011
vol. 92
 
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abstract:

REVIEW PAPER
Obesity and iron metabolism

Ewa Żekanowska
,
Joanna Boinska
,
Paulina Giemza-Kucharska
,
Justyna Kwapisz

BioTechnologia vol. 92(2) C pp. 147-152 C 2011
Online publish date: 2014/10/28
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Obesity and overweight have become a global problem affecting not only high income countries but also developing

countries. According to the World Health Organization (WHO) more than 1 billion adults are overweight and

at least 300 million of them are obese. Experimental and clinical studies indicate that there is a relationship between

iron metabolism and weight status. Iron deficiency is significantly more prevalent among obese individuals

compared to non-obese ones. Adipose tissue produces many pro-inflammatory cytokines (interleukin-1, interleukin-

6, tumor necrosis factor-α) and adipokines (leptin, adiponectin, resistin) that influence iron homeostasis.

According to recent studies, hepcidin, the main regulator of iron metabolism, can also be synthesized by the adipocytes.

Development of iron deficiency among obese and overweight children has potentially harmful effects,

which can lead to behavioral and learning problems as well as lowered resistance to infections. For this reason,

screening for iron status among children with elevated BMI should be recommended.
keywords:

obesity, iron metabolism, hepcidin

 
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