Regulation of alternative splicing by RNA secondary structure

The alternative splicing process is controlled by trans-acting factors and cis-acting elements. Initially, it was

thought that hnRNP proteins interact with the newly synthetized transcript and prevent the generation of a premRNA

secondary structure. However, there are many examples of the impact of secondary structure on the

alternative splicing of genes. An alternative splicing regulation is presented based on: the recognition of 5N and

3N splicing sites and branch sites, regulatory cis-acting elements, long-range interaction.