eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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1/2023
vol. 104
 
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abstract:
SHORT COMMUNICATIONS

A new approach to phosphorylation of nucleosides using oxyonium phosphobetaines as intermediates

Magdalena Materna
1
,
Jacek Stawiński
1, 2
,
MIchał Sobkowski
1

1.
Institute of Bioorganic Chemistry PAS, Poznań, Poland
2.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
BioTechnologia vol. 104(1) ∙ pp. 93–99 ∙ 023
Online publish date: 2023/03/27
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Oxyonium phosphobetaines are recently discovered molecules with a unique O–P–O–N+ bond system, which makes them useful and versatile intermediates for the synthesis of phosphates and their derivatives. In this paper, the preliminary data on the application of these compounds in nucleoside phosphorylation were presented.
keywords:

synthesis, phosphorylation, N-oxides, nucleotides, oxyonium phosphobetaines, H-phosphonates

 
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