COMMENTARY
A new division of bacterial UvrA homologues
Publication date: 2014-10-23
BioTechnologia 2013;94(1):54-56
ABSTRACT
The UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type
nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise
additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over
2400 bacterial genomes and found 130 examples of bacteria containing uvrA2 genes. The sequence analyses
conducted on these UvrA homologues revealed that the previously established division of UvrA proteins might
be based on some incorrect assumptions. In this paper, we present the reasons for our creation of a new division
of UvrA homologues and a description of the four UvrA classes we have created.
nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise
additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over
2400 bacterial genomes and found 130 examples of bacteria containing uvrA2 genes. The sequence analyses
conducted on these UvrA homologues revealed that the previously established division of UvrA proteins might
be based on some incorrect assumptions. In this paper, we present the reasons for our creation of a new division
of UvrA homologues and a description of the four UvrA classes we have created.
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| eISSN: | 2353-9461 |
| ISSN: | 0860-7796 |
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