In Memoriam: Professor Philippe Jeandet – an outstanding scientist and his legacy in natural product chemistry and bioactivity
 
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1
Department of Plant Physiology, Faculty of Agriculture, Horticulture and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
 
2
Molecular Biology and Genetics Section, Department of Biology, Faculty of Science, Ege University, Bornova, Izmir, Turkey
 
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Department of Mathematical and Statistical Methods, Faculty of Agriculture, Horticulture and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
 
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Institute of Molecular Physics, Polish Academy of Sciences, Poznań, Poland
 
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Department of Plant Physiology and Biotechnology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Poland
 
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Vinh University, Nghe An Province, Vietnam
 
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Polytechnic Institute of Huila, Universidade Mandume ya Ndemufayo, Lubango, Angola
 
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Department of Biochemistry and Biotechnology, Faculty of Agriculture, Horticulture and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
 
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Department of Plant Ecophysiology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland
 
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Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences – SGGW, Warsaw, Poland
 
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Department of Horticulture, University of Çukurova, Adana, Turkey
 
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University of Reims Champagne-Ardenne, INRAE, RIBP, USC 1488, ‘Induced Resistance and Plant Bioprotection’, Reims, France
 
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Department of Chemistry, School of Basic and Applied Sciences, K.R. Mangalam University, Gurugram, India
 
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Department of Biology and Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Poland
 
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Centro de Investigación en Ingeniería de Materiales-CIIMAT, Facultad de Medicina y Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile
 
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Plant Proteomics and Functional Genomics Group, Department of Biochemistry and Molecular Biology and Soil Science and Agricultural Chemistry, Faculty of Science, University of Alicante, Spain
 
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Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Damanhour University, AlBeheira, Egypt
 
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Dorothy and Fred Chau ‘71 Constellation Professor, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA
 
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Laboratory of Genetics and Genomics for Breeding, Department of Agronomy, Food, Natural Resources, Animals and Environment, University of Padova, Campus of Agripolis – V.le dell’Università 16, Legnaro (PD), Italy
 
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Department of Pharmacy, Southeast University, Dhaka, Bangladesh
 
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Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
 
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Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, San Salvatore Telesino, BN, Italy
 
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Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy
 
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Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain
 
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Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia-Regional Campus of International Excellence “Campus Mare Nostrum”, Murcia, Spain
 
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Department of Chemistry, University of Turin, Italy
 
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Department of Pharmacy, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Pakistan
 
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Department of Pharmacy, Korea University, Sejong, South Korea
 
 
Submission date: 2025-07-22
 
 
Acceptance date: 2025-08-01
 
 
Publication date: 2025-09-22
 
 
Corresponding author
Iwona Morkunas   

Department of Plant Physiology, Faculty of Agriculture, Horticulture and Biotechnology, Poznań University of Life Sciences, Poznań, Poland
 
 
BioTechnologia 2025;106(3):327-338
 
KEYWORDS
TOPICS
ABSTRACT
Professor Philippe Jeandet was one of the world’s leading biologists and plant biochemists, best known for his research on the chemical structure of natural products and their bioactivity, particularly that of stilbenoids. His scientific interests primarily focused on resveratrol (trans-3,5,4'-trihydroxystilbene), a stilbene with a wide range of biological activities. Additionally, his work highlighted the potential of combining pharmacological treatments with the use of natural products of plant origin, which have made significant contributions to the treatment of various diseases. He leaves behind a legacy of groundbreaking research and a lasting influence in the field. He was also involved in research on sugar signaling during plant responses to abiotic and biotic stress factors, as well as the role of signaling molecules in fruit development. His scientific achievements demonstrate that he was, first and foremost, a dedicated scientist – but also a honourable colleague who understood and respected the work of others.
REFERENCES (43)
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Adrian M, Jeandet P, Veneau J, Weston LA, Bessis R. 1997. Biological activity of resveratrol, a stilbenic compound from grapevines, against Botrytis cinerea, the causal agent for gray mold. J Chem Ecol. 23: 1689–1702. https://doi.org/10.1023/B:JOEC....
 
2.
Antoniraj MG, Devi KP, Berindan-Neagoe I, Nabavi SF, Kashani HRK, Aghaabdollahian S, Afkhami F, Jeandet P, Lorigooini Z, Khayatkashani M, et al. 2023. Oral microbiota in cancer: Could the bad guy turn good with application of polyphenols? Expert Rev Mol Med. 25: e1. https://doi.org/10.1017/erm.20....
 
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Ayvaz Sönmez D, Ürün I, Alagöz D, Attar ŞH, Doğu Z, Yeşil B, Woźniak A, Labudda M, Zydlik Z, Zydlik P, et al. 2021. Phenylalanine ammonialyase and invertase activities in strawberry fruit during ripening progress. Acta Horticult. 1309: 947–954. https://doi.org/10.17660/ActaH....
 
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Batista A, Mai VC, Sadowska K, Labudda M, Jeandet P, Morkunas I. 2025. Application of silver and selenium nanoparticles to enhance plant-defense response against biotic stressors. Acta Physiol Plant. 47(2): 21. https://doi.org/10.1007/s11738....
 
5.
Dambrouck T, Marchal R, Marchal-Delahaut L, Parmentier M, Maujean A, Jeandet P. 2003. Immunodetection of proteins from grapes and yeast in a white wine. J Agric Food Chem. 51(9): 2727–2732. https://doi.org/10.1021/jf0208....
 
6.
Donnez D, Jeandet P, Clément C, Courot E. 2009. Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms. Trends Biotechnol. 27(12): 706–713. https://doi.org/10.1016/j.tibt....
 
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Formela M, Samardakiewicz S, Marczak Ł, Nowak W, Narożna D, Bednarski W, Kasprowicz-Maluski A, Morkunas I. 2014. Effects of endogenous signals and Fusarium oxysporum on the mechanism regulating genistein synthesis and accumulation in yellow lupine and their impact on plant cell cytoskeleton. Molecules 19(9): 13392–13421. https://doi.org/10.3390/molecu....
 
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Formela-Luboińska M, Chadzinikolau T, Drzewiecka K, Jeleń H, Bocianowski J, Kęsy J, Labudda M, Jeandet P, Morkunas I. 2020a. The role of sugars in the regulation of the level of endogenous signaling molecules during defense response of yellow lupine to Fusarium oxysporum. Int J Mol Sci. 21(11): 4133. https://doi.org/10.3390/ijms21....
 
9.
Formela-Luboińska M, Remlein-Starosta D, Waśkiewicz A, Karolewski Z, Bocianowski J, Stępień Ł, Labudda M, Jeandet P, Morkunas I. 2020b. The role of saccharides in the mechanisms of pathogenicity of Fusarium oxysporum f. sp. lupini in yellow lupine (Lupinus luteus L.). Int J Mol Sci. 21(19): 7258. https://doi.org/10.3390/ijms21....
 
10.
Gougeon RD, Reinholdt M, Delmotte L, Miehé-Brendlé J, Jeandet P. 2006. Solid-state NMR investigation on the interactions between a synthetic montmorillonite and two homopolypeptides. Solid State Nucl Magn Reson. 29(4): 322–329. https://doi.org/10.1016/j.ssnm....
 
11.
Jeandet P, Bessis R. 1989. Une réflexion sur les mécanismes morphologiques et biochimiques de l’interaction vigne-Botrytis. Bull OIV. 62(703–704): 637–657.
 
12.
Jeandet P, Bessis R, Gautheron B. 1991. The production of resveratrol (3,5,4’-trihydroxystilbene) by grape berries in different developmental stages. Am J Enol Vitic. 42(1): 41–46. https://doi.org/10.5344/ajev.1....
 
13.
Jeandet P, Bessis R, Maume BF, Sbaghi M. 1993. Analysis of resveratrol in Burgundy wines. J Wine Res. 4(2): 79–85. https://doi.org/10.1080/095712....
 
14.
Jeandet P, Bessis R, Maume BF, Meunier P, Peyron D, Trollat P. 1995. Effect of enological practices on the resveratrol isomer content of wine. J Agric Food Chem. 43(2): 316–319. https://doi.org/10.1021/jf0005....
 
15.
Jeandet P, Capelli S, Laure M, Jégou S, Cirio A, Vasserot Y. 2008. Control of oxygen enrichment during bottling in the sparkling winemaking process. Food 2: 39–42.
 
16.
Jeandet P, Delaunois B, Conreux A, Donnez D, Nuzzo V, Cordelier S, Clément C, Courot E. 2010. Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants. Biofactors 36(5): 331–341. https://doi.org/10.1002/biof.1....
 
17.
Jeandet P, Douillet-Breuil AC, Bessis R, Debord S, Sbaghi M, Adrian M. 2002. Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism. J Agric Food Chem. 50(10): 2731–2741. https://doi.org/10.1021/jf0114....
 
18.
Jeandet P, Formela-Luboińska M, Labudda M, Morkunas I. 2022. The role of sugars in plant responses to stress and their regulatory function during development. Int J Mol Sci. 23(9): 5161. https://doi.org/10.3390/ijms23....
 
19.
Jeandet P, Heinzmann S, Roullier Gall C, Cilindre C, Aron A, Deville MA, Moritz F, Karbowiak T, Demarville D, Brun C, et al. 2015. Chemical messages in 170-year-old champagne bottles from the Baltic Sea: Revealing tastes from the past. Proc Natl Acad Sci U S A. 112: 5893–5898. https://doi.org/10.1073/pnas.1....
 
20.
Jeandet P, Sobarzo-Sánchez E, Uddin MS, Bru R, Clément C, Jacquard C, Nabavi SF, Khayatkashani M, El-Saber BG, Khan H, et al. 2021. Resveratrol and cyclodextrins, an easy alliance: Applications in nanomedicine, green chemistry and biotechnology. Biotechnol Adv. 53: 107844. https://doi.org/10.1016/j.biot....
 
21.
Jeandet P, Trotel-Aziz P, Jacquard C, Clément C, Mohan C, Morkunas I, Khan H, Aziz A. 2023b. Use of elicitors and beneficial bacteria to induce and prime the stilbene phytoalexin response: applications to grapevine disease resistance. Agronomy. 13(9): 2225. https://doi.org/10.3390/agrono....
 
22.
Jeandet P, Uddin MS, Clément C, Aziz A, Jacquard C, Khan H, Shah MA, Barka EA, Koffas M, Nabavi SM, et al. 2023a. Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems. Nat Prod Rep. 40: 1045–1057. https://doi.org/10.1039/D2NP00....
 
23.
Jeandet P, Vannozzi A, Sobarzo-Sánchez E, Uddin MS, Bru R, Martínez-Márquez A, Clément C, Cordelier S, Manayi A, Nabavi SF, et al. 2021. Phytostilbenes as agrochemicals: Biosynthesis, bioactivity, metabolic engineering and biotechnology. Nat Prod Rep. 38(7): 1282–1329. https://doi.org/10.1039/D0NP00....
 
24.
Labudda M, Jeandet P. 2025. Molecular advances in abiotic stress signaling in plants: Focus on atmospheric stressors. Int J Mol Sci. 26: 1878. https://doi.org/10.3390/ijms­2....
 
25.
Liger-Belair G, Jeandet P. 2002. Effervescence in a glass of champagne: A bubble story. Europhys News. 33(1): 10–14. https://doi.org/10.1051/epn:20....
 
26.
Liger-Belair G, Polidori G, Jeandet P. 2008. Recent advances in the science of champagne bubbles. Chem Soc Rev. 37: 2490–2511. https://doi.org/10.1039/B71779....
 
27.
Liger-Belair G, Tufaile A, Jeandet P, Sartorelli JC. 2007. Deterministic process of the transitions between different bubbling regimes of some nucleation sites in champagne and sparkling wines. Conference: Macromolecules and Secondary Metabolites of Grapevine and Wines. Intercept, Lavoisier. pp. 341–348.
 
28.
Mohan C, Jeandet P, Kumari N, Kumari P, Negi A. 2023. Synthesis of nano pigments using naturally-occurring clay minerals with enhanced thermal stability and their application as colorants in polymer matrixes. Micromachines 14(5): 1087. https://doi.org/10.3390/mi1405....
 
29.
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30.
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31.
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35.
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36.
Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Ashraf GM. 2022. Neuroinflammatory signaling in the pathogenesis of Alzheimer’s disease. Curr Neuropharmacol. 20(1): 126–146. https://doi.org/10.2174/157015....
 
37.
Vasserot Y, Mornet F, Jeandet P. 2010. Acetic acid removal by Saccharomyces cerevisiae during fermentation in oenological conditions. Metabolic consequences. Food Chem. 119(3): 1220–1223. https://doi.org/10.1016/j.food....
 
38.
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39.
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40.
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41.
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43.
Younes B, Cilindre C, Jeandet P, Vasserot Y. 2013. Enzymatic hydrolysis of thermo-sensitive grape proteins by a yeast protease as revealed by a proteomic approach. Food Res Int. 54(1): 1298–1301. https://doi.org/10.1016/j.food....
 
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