REVIEW PAPER
Microbial biotransformation of two phosphonoacetic acid
derivatives bearing two stereomeric centres
Publication date: 2014-10-23
BioTechnologia 2013;94(4):425-431
KEYWORDS
ABSTRACT
Three strains of microorganisms: Bacillus subtilis, Serratia liquefaciens and Escherichia coli were tested as
whole-cell biocatalysts for the kinetic resolution of isomers of two new phosphonoacetic acid derivatives. Used
compounds possess two chiral centres – one at the carbon adjacent to both functional groups and the other at the
phosphorus. Biocatalytic hydrolysis of 2-butyryloxy-2-(butoxyetoxyphosphinyl)acetic acid and 2-butyryloxy-2-(isobutoxyetoxyphosphinyl)
acetic acid with whole cells of Bacillus subtilis produced corresponding hydroxyphosphonates
with diastereoselectivity ranging from 50 to 60%.
whole-cell biocatalysts for the kinetic resolution of isomers of two new phosphonoacetic acid derivatives. Used
compounds possess two chiral centres – one at the carbon adjacent to both functional groups and the other at the
phosphorus. Biocatalytic hydrolysis of 2-butyryloxy-2-(butoxyetoxyphosphinyl)acetic acid and 2-butyryloxy-2-(isobutoxyetoxyphosphinyl)
acetic acid with whole cells of Bacillus subtilis produced corresponding hydroxyphosphonates
with diastereoselectivity ranging from 50 to 60%.
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| eISSN: | 2353-9461 |
| ISSN: | 0860-7796 |
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