REVIEW PAPER
Molecular mechanisms of lead toxicity
Publication date: 2015-01-29
BioTechnologia 2014;95(2):137-149
KEYWORDS
ABSTRACT
Lead is a ubiquitous xenobiotic metal and because of its widespread industrial use is one of the most serious environmental
pollutants. Lead is highly toxic and exposure to even low doses can produce adverse effects on all
living organisms. In humans, lead exposure can affect virtually all body systems, resulting in severe health problems.
On a molecular level, lead can alter or interfere with the activity of proteins and nucleic acids, ultimately
resulting in changes in cell metabolism and physiology leading to pathologic states. Lead can also affect the
functions of macromolecules, directly or indirectly, by inducing oxidative stress, which is regarded as a primary
factor in pathophysiology of lead exposure.
pollutants. Lead is highly toxic and exposure to even low doses can produce adverse effects on all
living organisms. In humans, lead exposure can affect virtually all body systems, resulting in severe health problems.
On a molecular level, lead can alter or interfere with the activity of proteins and nucleic acids, ultimately
resulting in changes in cell metabolism and physiology leading to pathologic states. Lead can also affect the
functions of macromolecules, directly or indirectly, by inducing oxidative stress, which is regarded as a primary
factor in pathophysiology of lead exposure.
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| eISSN: | 2353-9461 |
| ISSN: | 0860-7796 |
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