REVIEW PAPER
Nutritional content and renoprotective potential
of miracle tree (Moringa oleifera)
1
Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla, India
Submission date: 2024-08-29
Final revision date: 2025-04-26
Acceptance date: 2025-04-29
Corresponding author
Reena Gupta
Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla-171005, India
Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla-171005, India
BioTechnologia 2025;106(2):223-240
KEYWORDS
TOPICS
Infectious diseasesOther - medical biotechnologyOther - plant biotechnologyFood materials/ingredientsFunctional foods/nutriceuticalsOther - innovative foods and human nutrition
ABSTRACT
Kidney disease is a significant global health issue. This review explores the causes of renal illness, the therapeutic properties of the angiosperm Moringa oleifera, and its potential effectiveness in kidney disease management. In chronic kidney disease, inflammatory processes and immune cell activation lead to excessive free radical production, resulting in oxidative stress due to diminished antioxidant capacity. M. oleifera possesses diverse health benefits, particularly its ability to enhance antioxidant defenses. Extracts from its stem, seed, and leaf powders have been shown to increase the activity of key antioxidant enzymes, including glutathione, superoxide dismutase, and catalase. Additionally, M. oleifera modulates inflammation by reducing the activity of TNF-α, COX-2, and other pro-inflammatory cytokines. This review provides insights into the pharmacological and therapeutic potential of M. oleifera, highlighting its promise in the development of novel treatments for kidney-related disorders. Moreover, its bioactive compounds may contribute to renal tissue regeneration and protection against nephrotoxic agents.
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