REVIEW PAPER
Non-nucleosidic analogs of nucleic acids
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Publication date: 2014-10-28
BioTechnologia 2012;93(4):391-399
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ABSTRACT
This paper presents several analogs of nucleic acids, including their structure and selected physico-chemical properties,
reported recently as being obtained from non-nucleosidic units connected via phosphorodiester bonds.
These analogs are built from units that instead of sugar residues carry different diol structures functionalized
either with natural nucleobases or with other ring systems of an aromatic character. Some interesting nonnucleosidic
oligonucleotide analogs and their applications are described. Unlocked (UNA) and glycerol nucleic
acids (GNA) are also described.