REVIEW PAPER
Pathogenesis and clinical consequences of iron overload in chronic hepatitis C -- impact of host and viral factors related to iron metabolism
Pathogenesis and clinical consequences of iron overload in chronic hepatitis C -- impact of host and viral factors related to iron metabolism
Publication date: 2014-10-28
BioTechnologia 2011;92(1):54-65
KEYWORDS
ABSTRACT
Chronic hepatitis C virus infection is a leading cause of progressive liver fibrosis, liver cirrhosis and hepatocellular
carcinoma. Iron overload is frequently observed in cases of chronic hepatitis C and has been suggested as a negative
prognostic factor for this disease. Although the mechanisms leading to iron accumulation are not fully explained
yet, both host and viral factors seem to contribute towards the development of this pathology. Better understanding
of the interplay between hepatitis C virus replication and expression of iron regulatory molecules may
elucidate new and interesting targets for the effective treatment of chronic hepatitis C.
carcinoma. Iron overload is frequently observed in cases of chronic hepatitis C and has been suggested as a negative
prognostic factor for this disease. Although the mechanisms leading to iron accumulation are not fully explained
yet, both host and viral factors seem to contribute towards the development of this pathology. Better understanding
of the interplay between hepatitis C virus replication and expression of iron regulatory molecules may
elucidate new and interesting targets for the effective treatment of chronic hepatitis C.
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| eISSN: | 2353-9461 |
| ISSN: | 0860-7796 |
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