SHORT COMMUNICATION
RNA oligomers as microRNA production process regulators
Publication date: 2015-12-21
BioTechnologia 2014;95(4):272-275
ABSTRACT
The present invention relates to an RNA oligomer, methods for regulating’a microRNA (miRNA) production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre- iRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor’s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced
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| eISSN: | 2353-9461 |
| ISSN: | 0860-7796 |
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