REVIEW PAPER
Regulation of alternative splicing by RNA secondary structure
 
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Publication date: 2015-10-06
 
 
BioTechnologia 2014;95(3):181-186
 
KEYWORDS
ABSTRACT
The alternative splicing process is controlled by trans-acting factors and cis-acting elements. Initially, it was
thought that hnRNP proteins interact with the newly synthetized transcript and prevent the generation of a premRNA
secondary structure. However, there are many examples of the impact of secondary structure on the
alternative splicing of genes. An alternative splicing regulation is presented based on: the recognition of 5N and
3N splicing sites and branch sites, regulatory cis-acting elements, long-range interaction.
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